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Publications
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On a mission to discover and develop new therapies for various diseases, Boehringer Ingelheim researchers also author many scientific publications a year. These publications are part of a commitment to improve scientific knowledge by sharing critical and innovative research with the scientific community.
Below is a sample of some recent publications by Boehringer Ingelheim employees:
Ryan KR; Hong M; Arkwright PD; Gennery AR; Costigan C; Dominguez M; Denning D; McConnell V; Cant AJ; Abinun M; Spickett GP; Lilic D; Impaired dendritic cell maturation and cytokine production in patients with chronic mucocutanous candidiasis with or without APECED. Clin Exp Immunol 154 (3), 406-414 (2008)
Lo HY; Bentzien J; Fleck RW; Pullen SS; Khine HH; Woska Jr. JR; Kugler SZ; Kashem MA; Takahashi H; 2-aminobenzimidazoles as potent ITK antagonists: trans-stilbene-like moieties targeting the kinase specificity pocket. Bioorg Med Chem Lett 18 (23), 6218-6221 (2008)
Lee TW; Regan J; Bekkali Y; Bentzien J; Kulkulka AJ; Kahn J; Zuvela-Jelaska L; Souza D; Nabozny G; Thomson DS; Optimization of a quinolone class of dissociated glucocorticoid mimetics. Inflamm Res 57 (Suppl.[2]), S101 (2008)
Tatake RJ; O'Neill MM; Kennedy CA; Wayne AL; Jakes S; Wu D; Kugler Jr. SZ; Kashem MA; Kaplita P; Snow RJ; Identification of pharmacological inhibitors of the MEK5/ERK5 pathway. Biochem Biophys Res Commun 377 (1), 120-125 (2008)
Winters MP; Robinson DJ; Khine HH; Pullen SS; Woska Jr. JR; Raymond EL; Sellati R; Cywin CL; Snow RJ; Kashem MA; Wolak JP; King J; Kaplita PV; Liu LH; Farrell TM; DesJarlais R; Roth GP; Takahashi H; Moriarty KJ; 5-aminomethyl-1H-benzimidazoles as orally active inhibitors of inducible T-cell kinase (Itk). Bioorg Med Chem Lett 18 (20), 5541-5544 (2008)
Hercule HC; Schunk W-H; Gross V; Seringer J; Weldon S; Luft FC; Gollasch M; Interaction between P450 eicosanoids and nitric oxide in the control of arterial tone in mice: Implications for soluble epoxide hydrolase inhibition in hypertension. Hypertension 52 (4), E55 (2008)
Hu L; Chen R; Zimmitti C; Matera D; Brink C; Madwed J; Weldon S; AT1 receptor blockade with telmisartan prevents development of salt-sensitive hypertension and end-organ damage in dahl salt-sensitive rats. 13th Annual Meeting of the European Council for Cardiovascular Research, Nice (France), Oct 10-12, 2008 Hypertension 52 (4), E100 (2008)
Bhugra Ch; Shmeis R; Pikal MJ; Role of mechanical stress in crystallization and relaxation behavior of amorphous indomethacin. J Pharm Sci 97 (10), 4446-4458 (2008)
Bhugra Ch; Shmeis R; Krill StL; Pikal MJ; Different measures of molecular mobility: Comparison between calorimetric and thermally stimulated current relaxation times below T-g and correlation with dielectric relaxation times above T-g. J Pharm Sci 97 (10), 4498-4515 (2008)
Darkow Th; Chastek BJ; Shah H; Phillips AL; Health care costs among individuals with chronic obstructive pulmonary disease within several large, multi-state employers. J Occup Environ Med 50 (10) , 1130-1138 (2008)
Ma S; Shen S; Lee H; Yee N; Senanayake C; Nafie LA; Grinberg N; Vibrational circular dichroism of amylose carbamate: structure and solvent-induced conformational changes. Tetrahedron Asymmetry 19 (18), 2111-2114 (2008)
Liu W; Hickey ER; Chapter 11 protease inhibitors for the potential treatment of chronic obstructive pulmonary disease and asthma. Annu Rep Med Chem 43, 171-185 (2008)
Regan J; Razavi H; Thomson D; Chapter 9 advances toward dissociated non-steroidal glucocorticoid receptor agonists. Annu Rep Med Chem 43, 141-154 (2008)
Moriarty KJ; Winters M; Qiao L; Ryan D; DesJarlis R; Robinson D; Cook BN; Kashem MA; Kaplita PV; Liu LH; Farrell TM; Khine HH; King J; Pullen SS; Roth GP; Magolda R; Takahashi H; Itk kinase inhibitors: Initial efforts to improve the metabolical stability and the cell activity of the benzimidazole lead. Bioorg Med Chem Lett 18 (20) , 5537-5540 (2008)
Moriarty KJ; Takahashi H; Pullen SS; Khine HH; Sallati RH; Raymond EL; Woska Jr. JR; Jeanfavre DD; Roth GP; Winters MP; Qiao L; Ryan D; DesJarlais R; Robinson D; Wilson M; Bobko M; Cook BN; Lo HY; Nemoto PA; Kashem MA; Wolak JP; White A; Magolda RL; Tomczuk B; Discovery, SAR and X-ray structure of 1H-benzimidazole-5-carboxylic acid cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk). Bioorg Med Chem Lett 18 (20), 5545-5549 (2008)
Winters MP; Robinson DJ; Khine HH; Pullen SS; Woska Jr. JR; Raymond EL; Sellati R; Cywin CL; Snow RJ; Kashem MA; Wolak JP; King J; Kaplita PV; Liu LH; Farrell TM; DesJarlais R; Roth GP; Takahashi H; Moriarty KJ; 5-Aminnomethyl-1H-benzimidazoles as orally active inhibitors of inducible T-cell kinase (Itk). Bioorg Med Chem Lett Article in Press (2008)
Latli B; Hrapchak M; Easter JA; Stolle WT; Grozinger K; Krishnamurthy D; Senanayake CH; Synthesis of [C-14]- and [C-13(6)]-labeled tipranavir and its potential hydroxyl metabolite and the glucuronide conjugate. J Label Compd Radiopharm 51 (7-8), 314-320 (2008)
Latli B; Hrapchak M; Krishnamurthy D; Senanayake CH; An efficient synthesis of [13C6]-3,5-dichloroaniline. J Label Compd Radiopharm 51 (7), 283-285 (2008)
Farina V; Zeng X; Wei X; Xu Y; Zhang L; Haddad N; Yee NK; Senanayake CH; The chemistry of Ru cyclopropylmethylidene complexes: Mechanistic studies and synthetic implications for the ring-closing metathesis reaction. Catal Today Article in Press (2008)
Blum CA; Zheng XZ; Brielmann H; Hodgetts KJ; Bakthavatchalam R; Chandrasekhar J; Krause JE; Cortright D; Matson D; Crandall M; Ngo CK; Fung L; Day M; Kershaw M; De Lombaert S; Chenard BL; Aminoquinazolines as TRPV1 antagonists: Modulation of drug-like properties through the exploration of 2-position substitution. Bioorg Med Chem Lett 18 (16), 4573-4577 (2008)
Muegge I; Synergies of virtual screening approaches. Mini Rev Med Chem 8 (9), 927-933 (2008)
Takahashi H; Razavi H; Thomson D; Recent progress in the discovery of novel glucocorticoid receptor modulators. Curr Top Med Chem 8 (6), 521-530 (2008)
Goldberg DR; Choi Y; Cogan D; Corson M; DeLeon R; Gao A; Gruenbaum L; Hao MH; Joseph D; Kashem MA; Miller C; Moss N; Netherton MR; Pargellis CP; Pelletier J; Sellati R; Skow D; Torcellini C; Tseng Y-C; Wang J; Wasti R; Werneburg B; Wu JP; Xiong Z; Pyrazinoindolone inhibitors of MAPKAP-K2. Bioorg Med Chem Lett 18 (3), 938-941 (2008)